The problem of uncontrolled pain led early humans to seek remedies from any materials that they could lay their hands on. In recent times, focus on plant research has increased and non-steroidal anti-inflammatory drugs constitute one of the most widely used classes of drugs. Fever is a common medical sign characterized by an elevation of temperature above the normal range of 36.5-37.5�°C (98-100�°F). Herbal medicines are often used as remedies in these conditions. Piper attenuatum (B.Ham.) can cure Pyrexia as mentioned in the literature survey in traditional Indian system of medicine and is not proved scientifically so the aim of the present study is to determine the effect of Piper attenuatum (B.Ham.) on Pyrexia. In the study we induce pyrexia by using Brewer yeast in rats. Ethanolic extract of seeds part of plant was obtained by Soxhlet extraction. The extract was found to be safe up to 2000 mg/kg b.w. The Ethanolic extract of seeds part of Piper attenuatum (B.Ham.) contains active constituent like Piperine, Piperlonguminine etc. It may be possible that Piperine causes anti-pyretic activity. The Ethanolic extract of Plant showed significant results in the anti-pyretic model. A dose of 200 mg/kg & 400 mg/kg was used. Values are expressed as mean �± S.E.M. Paracetamol was used as standard drug (150mg/kg). The total time period of the study was 6 hr.
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